Svar 公司專注于大分子配體結合分析和基于細胞的分析研究，在抗體和多肽藥物、基因和載體的治療方面豐富有經驗，涉及領域包括腫瘤學、自身免疫、內分泌疾病和神經學相關研究領域，同時提供相關領域疾病的藥物和解決方案，提供完整的CRO 產品。
北京博蕾德生物是Svar 公司授權的中國區總代理，更多Svar 公司產品信息，請咨詢北京博蕾德生物科技有限公司。
以下是Svar 公司授權博蕾德生物為中國區總代理授權書。

特色產品推薦：
**補體檢測試劑盒
1）藥物開發-補體靶向治療
研究表明,炎性疾病的發生、發展同補體的活化有關。因此,如何干擾和抑制補體活化產生的有害作用,成為藥理學研究的焦點之一，Euro Diagnostica試劑盒用于評估補體靶向治療效果（參考文獻4-8）。
2）臨床研究-補體功能/活性監測
補體功能的評估在補體相關疾病的發生和治療中具有重要意義。文獻5-9 用Euro Diagnostica試劑盒監測補體疾病治療中補體水平。
3）補體脫靶反應
在某些情況下，補體激活可引起嚴重反應，比如候選藥物的脫靶反應，抗體依賴的補體激活，移植排斥反應。（（參考文獻12-13）。）
訂購信息

貨號	產品名稱	規格
COMPL300	Complement system Screen WIESLAB®	96T
COMPLCP310	Complement system Classical Pathway WIESLAB®	96T
COMPLMP320	Complement system MBL pathway WIESLAB®	96T
COMPLAP330	Complement system Alternative Pathway WIESLAB®	96T

應用文獻：
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the complement system: standardization and validation of a simple ELISA. J Immunol Meth 2005; 296: 187–198
3. Salvesen B and Mollnes TE. Pathway-specific complement activity in pigs evaluated with a human functional complement assay. Mol Imm 2009;6:1620-1625
4.Hill A et al. A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Interim Phase 1 Study Results. Abstract 2413 ;58th ASH Annual Meeting 2015
5. Jore MM et al. Structural basis for therapeutic inhibition of complement C5. Nature Structural & Molecular Biology 2016: doi:10.1038/nsmb.3196
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Protease (MASP)-1 and -2: Significant Contribution of MASP-1 to Lectin Pathway
Activation. J of Immunol 2010;185: 4169–4178
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complement system activity of the newborn. Immunobiology 2015; 220:452–459
12. Castellano G et al. Therapeutic Targeting of Classical and Lectin Pathways of Complement Protects from Ischemia-Reperfusion- Induced Renal Damage. Am J Pathol 2010; 176:1648–1659
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14. Mitsuru Sugimoto,etal.Possible participation of IgG4 in the activation of complement in IgG4-related disease with  hypocomplementemia.Modern Rheumatology,Volume 26, 2016 - Issue 2
15．Y. Palarasah,etal.Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system.Clincal&Experimental Immunology,Volume164, Issue3,June 2011,Pages 388-395.